Colestipol hydrochloride Property

storage temp. 

Room Temperature, under inert atmosphere

form 

Solid

color 

Off-White to Pale Yellow

Safety

WGK Germany 

3

HS Code 

3914006000

Toxicity

LD50 in rats (mg/kg): >4000 i.p.; >1000 orally (Webster, Bollert)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Colestipol hydrochloride Chemical Properties,Usage,Production

Uses

Antihyperlipidemic.

Uses

Colestipol Hydrochloride was useful for studying pharmacokinetics with Teriflunomide (A771726).

Definition

ChEBI: The hydrochloride of colestipol, a highly cross-linked, high molecular weight copolymer of diethylenetriamine and epichlorohydrin (hydrochloride), with approximately 1 out of 5 amine nitrogens protonated. It is used for binding bile acids in the intestine, inhibiting their reabsorption.

brand name

Colestid (Pharmacia & Upjohn).

General Description

Colestipol (Colestid) is ahigh–molecular-weight, insoluble, granular copolymer oftetraethylenepentamine and epichlorohydrin. It functions asan anion-exchange, resin-sequestering agent in a manner similarto that of cholestyramine resin. Colestipol hydrochloridereduces cholesterol levels without affecting triglycerides andseems to be especially effective in the treatment of type IIhyperlipoproteinemias.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: may enhance or reduce effects of coumarins and phenindione.
Ciclosporin: no reports of an interaction; however, ciclosporin levels should be carefully monitored if colestipol and ciclosporin are prescribed concurrently, as colestipol may interfere with ciclosporin absorption.

Metabolism

Not applicable as colestipol is not systemically absorbed.